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KMID : 0369819940240040245
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Jorunal of Korean Pharmaceutical Sciences
1994 Volume.24 No. 4 p.245 ~ p.250
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Synthesis and Antitumor Activity of Pt (Ⅱ ) Complexes Containing Ethylenediamine
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이경태/Lee KT
정지창/노영수/Jung JC/Roh YS
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Abstract
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An attempt was made to develop new water-soluble antitumor Pt(ll) complexes containing ethylenediamine, and their structures were determined by infrared spectroscopy, 13C nuclear magnetic resonance and elemental analysis. Their antitumor activities in vitro against L-1210, p-388 leukemia cells and M-14 melanoma cells were investigated and acceptable antitumor activity was found as compared with cisplatin.
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KEYWORD
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Platinum(ll) complexes, Antitumor activity, L-1210, p-388 leukemia cells, M-14 melanoma cells
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